Chitosan nanoparticles release nimodipine in response to tissue acidosis to attenuate spreading depolarization evoked during forebrain ischemia
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چکیده
منابع مشابه
Ischemia-induced spreading depolarization in the retina.
Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known, however, whether spreading depolarization also occurs in the retina in vivo. We report now ...
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Purpose: The aim of this work was to prepare nimodipine-loaded alginate-chitosan beads for sustained drug release. Methods: Nimodipine-loaded alginate-chitosan beads were prepared by ionic gelation method using various combinations of chitosan and Ca 2+ as cations and alginate as anion. The swelling ability and in vitro drug release characteristics of the beads were studied at pH 1.2 and 6.8. I...
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BACKGROUND AND PURPOSE We explored the effectiveness of dual blockade of calcium channels in preventing ischemic necrosis in a rat model of transient forebrain ischemia. METHODS To assess all the major brain regions, the entire brain was subserially sectioned and examined histologically 1 week after ischemia in 44 male Wistar rats. Brain temperature was monitored and controlled to avoid hypot...
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In various functional conditions involving peripheral vasoconstriction a more or less widespread change toward acidity takes place within certain tissues. The change is frequently independent of any in the blood. Indeed the blood can become more alkaline while the tissue acidosis is developing. When the blood volume is diminished abruptly but not too greatly, by hemorrhage or by anhydremia, the...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2020
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2019.107850